2012-11-01
The metabolism of opioids closely relates to their chemical structure. Opioids are subject to O-dealkylation, N-dealkylation, ketoreduction, or deacetylation leading to phase-I metabolites. By glucuronidation or sulfatation, phase-II metabolites are formed.
2012-11-01
Oxycodone has been in clinical use since 1917. Parenteral oxycodone was used mainly for the treatment of acute postoperative pain whereas combinations, for example, oxycodone and acetaminophen, were used for moderate pain.
2012-11-01
Patient-controlled analgesia (PCA) has become the gold standard for acute pain management since it was first introduced 20 years ago, and its merits have been discussed in quite a large number of publications.
2012-11-01
Fentanyl, a potent lipid-soluble opioid which was first synthesized more than 40 years ago, is still the most popular opioid used in the perioperative period throughout the world.
2012-11-01
Hydromorphone is a semi-synthetic opioid that has been used widely for acute pain, chronic cancer pain and to a lesser extent, in chronic nonmalignant pain.
2012-11-01
Opioids provide excellent pain relief in most patients. Yet the responses of patients to individual opioids can vary markedly, even among the μ opioids. Understanding this variability would greatly enhance our ability to treat patients appropriately.
2012-11-01
Pain is the cancer-related event that is most disruptive to the cancer patient s quality of life.
2012-11-01
Research on comorbidity across cancer symptoms, including pain, fatigue, and depression, could suggest if crossover effects from symptom-specific interventions are plausible. Secondary analyses were conducted on a survey of 268 cancer patients with recurrent disease from a northeastern U.S.
2012-11-01
Objectives To systematically review studies of antiemetics used in the treatment of nausea in patients with far-advanced cancer.
Data sources Randomized controlled trials (RCT) and uncontrolled studies identified by electronic and hand searching.
Review methods Identified studies were appraised fo
2012-11-01
Seventy patients with advanced cancer and refractory emesis were treated with subcutaneous boluses of levomepromazine (median daily dose: 6.25 mg; range: 3.12–25) in an open-label prospective study.
2012-11-01
About Us
Quality of Life Publishing Co. is a direct outgrowth of our founder's personal and professional hospice experience. Karla Wheeler has been a hospice volunteer for 16 years, and four members of her immediate family have been blessed by hospice and palliative care.
2012-11-01
Il n'y a pas d'abstract, car c'est un «letter», mais en gros ils rappellent que les patients recevant de la radiothérapie et étant sous opiacé pour un problème de douleur, doivent à l'occasion diminuer les laxatifs, car la radiothérapie , avec l'entérite possible , dépendant
2012-11-01
We investigated the drugs used in the alleviation of pain and symptoms (APS) with a possible life-shortening side effect in six European countries' end-of-life care. We sent mail questionnaires to physicians who signed a representative sample of death certificates in each country.
2012-11-01
We investigated the drugs used in the alleviation of pain and symptoms (APS) with a possible life-shortening side effect in six European countries' end-of-life care. We sent mail questionnaires to physicians who signed a representative sample of death certificates in each country.
2012-11-01
Objective:
To study and explore problems perceived by physicians when breaking bad news to advanced cancer patients about discontinuing or not offering tumor-specific treatment due to incurable cancer.
Design:
A qualitative phenomenographic interview study.
Setting:
The county of Östergöt
2012-11-01
The neurobiology of itch, which is formally known as pruritus, and its interaction with pain have been illustrated by the complexity of specific mediators, itch-related neuronal pathways and the central processing of itch.
2012-11-01
Achieving the best quality of life for patients and their families when a disease becomes progressive and no longer remains responsive to curative therapy is the primary goal of palliative care.
2012-11-01
Cancer pain often presents in a body region. This review summarizes articles from 1999–2004 relevant to cancer pain syndromes in the head and neck, chest, back, abdomen, pelvis, and limbs.
2012-11-01
While patients with short bowel syndrome are not common in palliative care, they can present challenges for palliative care professionals. The case presented highlights a specific difficulty encountered.
2012-11-01
A patient was seen on the palliative care service at our institution who developed serotonin syndrome and mutism associated with methadone use.
2012-11-01
Cachexia is a disturbing and disfiguring aspect of many advanced cancers. Parenteral nutrition (PN) is a controversial and expensive treatment for cancer cachexia. Guidelines for the use of PN for these patients have been suggested.
2012-11-01
Approximately two-thirds of patients with bone metastases have severe and debilitating pain. Despite a range of treatments, about 25% of patients with painful bone metastases suffer from uncontrolled pain.
2012-11-01
RATIONALE: Cough is the most common complaint for which medical attention is sought, and chronic cough can be both physically and mentally debilitating. There is currently no evidence supporting the use of antitussives in chronic treatment-resistant cough.
2012-11-01
Patients with neuropathic pain (NP) are challenging to manage and evidence-based clinical recommendations for pharmacologic management are needed. Systematic literature reviews, randomized clinical trials, and existing guidelines were evaluated at a consensus meeting.
