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An Observational Study of Insomnia and Nightmare Treated With Trazodone in Patients With Advanced Cancer
Date de l'article :
2013-07-03
Auteurs :
Hitoshi Tanimukai, MD, PhD1,2, Tasuku Murai, BP2,3, Namiko Okazaki, MD2,4, Yoichi Matsuda, MD2,5, Yoshiaki Okamoto, BP6, Yasunobu Kabeshita, MD1, Yumiko Ohno, MSN, CNS2,7, and Satoru Tsuneto, MD, PhD2,4
Affiliations :
1 Department of Psychiatry, Osaka University Graduate School of Medicine,
Japan
2 Palliative Care Team, Oncology Center, Osaka University Hospital, Japan
3 Department of Pharmacy, Osaka University Hospital, Japan
4 Department of Palliative Medicine, Osaka University Graduate School of
Medicine, Japan
5 Department of Anesthesiology and Intensive Care Medicine, Osaka University
Graduate School of Medicine, Japan
6 Department of Pharmacy, Ashiya Municipal Hospital, Japan
7 Division of Nursing, Osaka University Hospital, Japan
Source :
American Journal of Hospice & Palliative Medicine® 30(4) 359-362
Abstract :
Patients with cancer often experience insomnia. Nightmares are also a strong factor that interferes with the maintenance of
comfortable and satisfying sleep. However, the prevalence and standard treatment of nightmares in patients with cancer have
not been established yet. We aimed to treat insomnia and nightmares with trazodone. From 2008 to 2011, trazodone was
prescribed to 30 patients with cancer who reported experiencing insomnia with or without nightmares to the palliative care
team in Osaka University Hospital. Effective treatment was seen in 15 patients (50%). Four patients with cancer reported
having severe nightmares and 2 patients had beneficial effects, with frightening dreams transformed into acceptable ones.
Trazodone may be an effective drug for the treatment of insomnia and nightmares in patients with advanced cancer.
Keywords
cancer patients, insomnia, nightmare, sleep avoidance, trazodone, antidepressant, hypnotics
Commentaires :
Article qui donne une suggestion de plus pour les problèmes de rêves difficiles […]